메뉴 건너 뛰기
SinilPharm

Major Research Outcome

Major Research Outcome

R&D Pipeline R&D Center Introduction

Developed Osteoarthritis treatment drug (SI-000413)

Subject Name
Development of drugs for treating and improving incurable diseases
Supervision
the Ministry of Knowledge and Economy (Local Industrial Promotion Project)
Development period
2004. 12. 01~2008. 09. 30

Research Details

Study on Action Mode of Osteoarthritis treatment drugs
Study on Natural substance-based treatment drugs with fewer side effects
Study on herbal drugs with fewer side effects
Study on herbal drugs and formulation

Result

Dong-A Pharmaceutical Co., Ltd. licensing out after Pre-Clinical Study
Completed Phase2 of Clinical Trial (Seoul National University Hospital, Kyung Hee University Medical Center, Ajou University Hospital)

Domestic and foreign patent

•Complex herbal medicines for treating or preventing inflammatory diseases (10-0847440, USA/Japan/China patent registered, Europe/India patented)

•Drugs for treating or preventing inflammatory diseases containing Trachelospermum caulis extracts are patented in China.

•Pyrola japonica Klenze extracts for treating or preventing inflammatory diseases (10-0836559)

•Osmanthus heterophylla extract compositions for treating or preventing inflammatory diseases (10-0779026)

Overseas SCI(Science Citation Index) Thesis

•In-vitro and in-vivo anti-inflammatory action of the ethanol extract of Trachelospermi caulis (J. Pharm Pharmacol, 2007)

•The anti-inflammatory effects of Pyrolaeherba extract through the inhibition of the expression of inducible nitric oxide synthase (iNOS)

•and NO Production (J. Ethnopharmacol, 2007)

•Treatment with SI000413, a new herbal formula, ameliorates murine collagen-induced arthritis (Biol Pharm Bull, 2008)

Development of rheumatoid arthritis treatment drugs (SI-000902)

Subject Name
Development of rheumatoid arthritis treatment drugs using natural substances
Supervision
the Ministry of Knowledge and Economy(Local Industrial Promotion Project)
Development period
2008. 12. 01~2011. 09. 30

Research details

Study on action mode of rheumatoid arthritis treatment drugs
Study on natural herb treatment drugs with fewer side effects
Study on herbal formulation and forms
Study on mechanism of rheumatoid arthritis

Result

Phase2 of Clinical Trial is IND certification after completion, Korea Underway

Domestic and foreign patent

•Manufacturing of pharmaceutical compound treatment drugs for treating or preventing inflammatory diseases including Trachelospermum asiaticum var and Paeonia suffruticosa extracts(10-1298243, USA/Europe/Japan/China patent applied)

•Pharmaceutical compounds for treating or preventing inflammatory diseases including Novel PHENYL ESTER compounds (10-1247706)

•Pharmaceutical compounds for treating or preventing inflammatory diseases including acetate fraction of Trachelospermum caulis dry extracts as active ingredient(10-1192409, USA/Japan/China patented, Europe patent applied)

Composition for Oral administration and method for the production thereof (10-1330142)

Overseas SCI(Science Citation Index) Thesis

•A mixture of Trachelospermi caulis and Moutan cortex radicis extract suppresses collagen-induced arthritis in mice by inhibiting NF-κB and AP-1 (Journal of Pharmacy and Pharmacology, 2011)

•Bioactivity-Guided Isolation of Novel compound from Paeonia suffruticosa Andrews Roots as an IL-1β inhibitor (Archives of Pharmacal Research, 2012)

•Anti-inflammatory effects of β-sitosterol-β-D-glucoside from Trachelospermum jasminoides (Apocynaceae) in Lipopolysaccharide-stimulated RAW264.7 Murine Macrophages (Natural Product Research, 2012)

•Anti-inflammatory and immunosuppressive activity of mixture of Trachelospermum asiaticum and Paeonia suffruticosa extracts (Novel herbal formula SI000902) (Journal of Medicinal Plants Research, 2012)

•Arctigenin suppresses osteoclast differentiation by RANKL through the inhibition of Syk activation in bone marrow-derived macrophages and in vivo (European journal of Pharmacology, 2012)